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What is Defyne?

Defyne is an injectable within the Restylane family of dermal fillers that uses specifically formulated hyaluronic acid to correct deep nasolabial or marionette lines around the nose and mouth. Hyaluronic acid is a substance found in the skin that is responsible for moisture retention, and Defyne uses special cross-linking technology to help the gel support common facial movements around the mouth and nose with long-lasting results.

Your Customized Defyne Consultation

Your first step in injectable treatment is a consultation with our team, who can determine which injectable would suit your aesthetic goals best. You should be sure to ask any questions you may have about the procedure and describe your intended results. Our team can ensure you know what to expect from this treatment and create a treatment plan that may include skin or surgical treatments at our professional recommendation. 

The Treatment Process

Injectable treatments begin with a topical anesthetic to ensure that you’re comfortable during the procedure. Then, our injectors carefully begin placing the crystal-clear gel with a very small needle into the treatment area. This can require multiple small injections to ensure your results look natural, and our team will ensure you know how much product will be required during your consultation. Depending on how extensive your goals are, injectable treatments can take 15 to 30 minutes.

Recovery and Results

You can expect some bruising and swelling after your injectable treatment, but it usually subsides within the day. If you experience any discomfort, you can manage it with the use of an ice pack. Defyne can last for up to one year, after which you can opt for another treatment or discuss your other options with our team.

Restylane Defyne FAQs

What is Restylane Defyne used for?

Defyne is a hyaluronic acid that can be used for multiple areas of the face. Its on-label indication is for chin retrusion and nasolabial folds.

Can you use Restylane Defyne in lips?

Yes! If you are looking for more structure and volume in your lips, this would be a good option. It is important to keep in mind, that your injector will choose the most appropriate product for you based on what your desires are.

How much does Restylane Defyne cost?

One syringe of defyne costs $700.

What is the difference between Restylane Refyne and Defyne?

Due to its hyaluronic acid gel formula, Refyne is a more flexible filler. We would use Refyne typically for areas that are more mild to moderate like the fine lines that can develop around the lips. Defyne is better for more moderate to severe lines and wrinkles and for structural improvement.

How long does Restylane Defyne last in lips?

It can last 6 months - 1 year, maybe longer depending on the individual.

Where is Restylane Defyne used?

Defyne can be used in marionette folds, cheeks, jawline, and even temples. Because it is a stronger hyaluronic acid gel formulation, it is great in areas that need more structural support.


At Grace and Grey Spa, we combine state-of-the-art medical procedures with scientifically proven skincare products and treatments so all of our patients look & feel their very best.

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